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IgE vs IgG Food Allergies

While we know that our immune system responds to any type of allergy, food allergies can be of two types. One that produces IgE antibodies as a reaction to an allergen and the other that produces IgG antibodies. The IgE food allergy is also called a Type I allergy while the IgG food allergy is classified as a Type III or food intolerance.

IgE Food Allergy

A classic type I allergy is when the immune system produces specific IgE antibodies (immune globulins of the subclass E). These antibodies lead to an immediate allergic reaction. The symptoms appear within seconds or minutes: severe swelling, breathing difficulty, rash, itching skin or even anaphylactic shock.

Someone who has a type I allergy will most probably know which food is causing problems, because the symptoms appear right away. Therefore, blood testing is not necessarily needed to identify this kind of allergy. IgE tests are mainly performed for confirmation. ImuPro does not detect type I food allergies.

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Delayed IgG food allergy

A type III food allergy is when the immune system produces specific IgG antibodies (immune globulins of the subclass G). These antibodies can lead to inflammatory processes. The symptoms appear up to three days after the consumption of a trigger food.

It is very difficult to pinpoint which food causes you problems because of the delayed appearance. An IgG test helps to localise and limit the suspects.

With ImuPro you will only have to avoid foods with elevated IgG antibody values. This means that you can maintain a diverse and varied diet and don't need to restrict yourself unnecessarily. You might need to avoid salmon, for instance, but be able to eat all other fish. After a certain period of avoidance, you may reintroduce one food after the other into your diet and monitor your symptoms. This provocation phase is the crucial step to identify your personal "trigger foods".

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Comparison table of IgE and IgG food allergies
Differences IgE Food Allergy (Type I) IgG Food Allergy (Type III)
Immune response IgE antibodies produced Release of histamine mediated by IgE antibodies IgG antibodies produced Release of inflammatory mediators caused by binding of IgG antibodies
Food allergy symptoms Itching, red skin, anaphylaxis, swelling of mucous membranes Chronic inflammatory ailments like constipation, Crohn's disease, diarrhoea, eczema, flatulence, Irritable Bowel Syndrome (IBS), migraines, psoriasis, obesity
Onset of symptoms Immediate reaction within a few minutes or even seconds Several hours or days later
Diagnostics Prick test or IgE blood test + food challenge test IgG blood test + food challenge test