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Why does everyone digest food in a different way?

Humans have evolved to adapt to various lifestyles and dietary needs, and their genes have altered their metabolism to do so. The metabolism's effectiveness in processing macronutrient (carbohydrates, proteins, and fats) as well as your caloric intake during various sporting activities might be impacted by minor variations in the DNA, known as polymorphisms, that differ between persons.The word nutritional genetics (nutrigenetic) is also used in this sense.Four forms of genetic metabolism have been identified by CoGAP® (Meta-types).

These genetic variances make sure, among other things, that every person processes food differently. Every time you come across friends or family that are leaner or stronger, you may relate to this conclusion from your own experience.

What underlying idea drives CoGAP MetaCheck®?

These genetic variants serve as the starting point for the CoGAP® metabolic study. The objective is not just any generic diet; rather, it should take into account your unique Meta-type as identified by CoGAP® and provide support through expert nutrition and exercise advice.

The CoGAP MetaCheck® is a genetic metabolic analysis that identifies the Meta-type and its effects in persons who are seeking help. By identifying the Meta-types, you may provide cutting-edge dietary and exercise guidance as a MetaCheck consultant. Retrospective investigations have already been carried out in the United States and at the German Sport university of Cologne's Center for Health. Clinical research has not yet confirmed the relationship between genetic predisposition and weight change satisfactorily. CoGAP is sure, though, that a diet that takes into account the genetic traits of the person seeking guidance can produce better outcomes than a diet that disregards these physiological traits.

The different COGApO Meta-Types

The four Meta-types that CoGAP® identifies are Alpha (a), Beta (B), Gamma (v), and Delta (6). Each of these Meta-types processes the food's macronutrients in a unique way, in theory.

Moreover, CoGAP® assigns one of the two activity variants—E for "Endurance" or S for "Speed"—to each Meta-type. Depending on the type of activity, these exercise variations can have varying calorie consumption rates, according to CoGAP®. Procedu consultation and sample collection (cheek swab) the sample being sent to the lab Results delivery and analysis a follow-up meeting

Analysis results & Billing the CoGAP MetaChecks®

Presentation for people seeking help is straightforward and transparent. Personalized dietary and exercise advice that takes into account personal objectives and traits (gender, age, height, and weight) nutritional chart Use of the CoGAP® nutrition kiosk Population Genetic Study Distribution of CoGAP Meta-Types in Europe No general "one-size-fits-all" weight-loss plan exists.I The distribution of the CoGAP Meta-Types in the European population was examined as part of a significant scientific investigation by the Center of Genetic Analysis and Prognosis and Fresenius University of Applied Sciences. 13) A potential relationship between the various Meta-Types and Sports-Types and demographic information, such as age, gender, and BMI, has been examined in this study.

The study's greatest level of significance was attained by using the anonymised data of 16,641 randomly chosen MetaCheck findings from various European areas. The findings demonstrate that the population's distribution of the four distinct Meta-Types—Alpha, Beta, Gamma, and Delta—is comparatively equal (Fig. a). The Sport-Types E and S, on the other hand, exhibit major variances (Fig. b). About twice as many people own a Sport-Type E.

Figure a- shows the distribution of the various Meta-Types in the population of Europe. as shown in -Fig. b.- Distribution of the two various Sports-Types E and S in the European population The prevalence of various Meta- and Sports-type combinations in the population of Europe.

Nowadays, cutting back on carbohydrates or following a "low-carb diet" in conjunction with endurance exercises is the weight loss strategy that is most frequently advised. The Meta-Type Beta and Sport-Type Endurance, which only apply to 12% of the European population, would be equal to the recommendations given here (Figure c.).

Only 12 out of 100 people who follow a low-carb diet and an endurance training regimen will successfully reduce weight over the long run.The study's findings also demonstrated that there is no relationship between the various Meta-Types or Sports-Types and the participant demographics of age, gender, or BMI.

This demonstrates that there is no connection between the specific Meta-Types and Sports-Types and an increased risk of being overweight. Moreover, there is no distinction between gender, size, or age in the Meta-Types and Sports-Types.

The findings of the study demonstrate that generic advice, such as a "low-carb" diet, is not helpful for everyone to lose weight. Individualized weight-loss therapy based on the patient's particular characteristics, especially based on their Meta-Types, are actually very needed. As a result, when developing a weight loss programme, special attention must be paid to each person's genetics.

Advantages of the CoGAP MetaCheck® concept

For you as a doctor

  • Picture gain (modern, innovative) for each person

  • Persistent dedication

  • A cutting-edge service

  • Simple management of testing

  • A personalised dietary plan has a high adoption rate (45%)(3) without charge

For those who want guidance

  • Guidelines for diet and exercise that are customised

  • Variations in diet throughout time

  • Notion of weight loss based on a single genetic test

  • Enough is a simple cheek swab sample.

  • The CoGAP® nutrition site is available

The CoGAP® nutrition portal

The CoGAp® nutrition portal offers diet and nutrition plans, as well as Meta-type-appropriate recipes that have been calorically adjusted, for individuals looking for advise. Other personal variables, such as gender, age, height, weight, and level of physical activity, are also taken into consideration in addition to Meta-types. individualised meal plansindividualised recipe recommendations Calorie requirements, a BMI calculator, and a page with advice on nutrition and exercise.


The groundbreaking meal substitute Each Meta-Type has a special meal substitute called a MetaShake® that is tailored to your particular genetic makeup. It makes weight loss easier in the busy and time-consuming daily life! It is a great substitute for your Meta-Type meals, particularly during stressful conditions.

What advantages does the MetaShake® offer?

The MetaShake® with real vanilla is lactose-free, gluten-free, and vegetarian-friendly and contains no additives. The shake has a lot of fibre, which makes you feel fuller and promotes healthy digestion. The vitamins, minerals, and nutrients that your body requires for a balanced diet that matches your Meta-Type are also included in it.

How to use the MetaShake®?

You can substitute your customised MetaShake® during the day for two full meals, such as breakfast and dinner, in order to lose weight.You can swap out one meal every day if you've attained your weight goal and want to maintain it.The shake is quite easy to make. In a shaker cup, combine a sachet with 200 ml of water and 60 g of MetaShake powder. Shake well. Your shake is now prepared for consumption.

CoGAP MetaCheck® has proven itself!

An empirical study that was conducted in 2016 assessed the longevity of weight loss using MetaCheck. The sustainability of weight loss success using the MetaCheck was assessed using quantitative surveys. The study also looked into whether or not the genetics component of MetaCheck consultants' consultations is seen as a valuable addition.

The majority of MetaCheck consultants—nearly 96%—said that the MetaCheck analysis is a helpful supplement to their expert nutritional advice Also, according to their Meta-Type, 87% of their clients reported feelin more at ease following a diet adjustment. 91% of the clients reported being able to maintain their new weight. (5] **Nutritional counselling with the MetaCheck is a helpful addition (%) The newly attained weight was received (%).

Scientific basis of the CoGAP MetaCheck®

A complicated calculation of genetic interactions is performed within the CoGAP MetaCheck® framework, only taking into consideration the genes whose effects have been demonstrated to meet the strict standards used by our scientists.Only those metabolic gene variants that, according to our research, cover many areas, such as glucose or fat metabolism, and can be attributed to the various Meta-types are examined in our labs. selection of the metabolic genes for analysis They include metabolic genes in particular, of which we are confident that they play a role in the body's system for regulating weight, that their impact on the body can be positively altered by a change in diet or behaviour, and that they vary greatly from person to person.

A comparison with scientific studies#4] that must satisfy the following standards for quality is done in addition to the genetic analysis. Replication of study findings adequate sample size for the study Significance (significance level) (significance level) dependable research techniques The following genes were determined based on these parameters and added to the CoGAP MetaCheck® analysis after carefully evaluating the pertienent studies.

Genes relevant to CoGAP MetaCheck®

The second most prevalent HDL protein in the body, apolipoprotein |I (apoII), is encoded by the ApoA2 gene. By allowing lipids to be absorbed, changes in the gene cause an above-average weight gain. Insulin resistance may result .

The FABP2 gene's impact on fat absorption and oxidation. Firmer bonds to fatty acids are produced as a result of gene changes, which significantly affects how well fatty acids are absorbed by the body. Due to the increased absorption of fatty acids in the small intestine caused by this, gaining additional weight after consuming fatty foods is more likely.

The hypothalamus and the pancreatic Langerhans islets both have high levels of FTO gene expression. A sense of satiety is not brought on by the overexpression of the gene, which controls how much energy is consumed. The rate of fat burning during repetitive motion is also impacted by gene changes.Hence, increased calorie consumption can be attained through endurance sports when such gene variations are present.An essential receptor for the transformation of fat molecules into energy is encoded by the ADRB2 gene. This gene is therefore crucial for the breakdown of fat from fat cells. Moreover, endurance sports can be used to lose weight more quickly and effectively in people with specific variations of this gene.

The ADRB3 gene controls thermogenesis and lipolysis and is primarily expressed in fatty tissue. Deterioration of lipolysis and decreased fat burning during endurance exercise may result from gene changes. In the processing of fat molecules, The PPARG gene is crucial. It significantly affects how glucose and insulin are metabolised.Hence, eating carbohydrates and lipids promotes weight gain due to specific alterations in this gene.

The IL-6 gene produces a class of cytokines that play a number of roles in inflammation and B-lymphocyte development. Due to an inflammatory signal transduction during glucose absorption, those who carry specific IL-6 gene variations are more likely to put on weight.

A specific bio-information evaluation software is used to evaluate the data. A suitable workout variant for weight loss is identified for each person seeking guidance based on their specific Meta-type. The analysis's findings prevent any family-related inferences from being made.

CoGAP® as partner of medicine and science

The Centre of Genetic Analysis and Prognosis - or CoGAP® - is a company based in the heart of Cologne. In cooperation with the University of Cologne and the Fresenius University of Applied Sciences, CoGAP® works to advance genetic studies in the healthcare industry. The goal is to help the population's overall health and to make it possible for people to lead healthy lives well into old age.Hence, CoGAP® gives you the chance to do cutting-edge genetic studies for individual health as a MetaCheck consultant. The collaboration aims to make genetic assessments, which are based on scientific discoveries in human genetics, accessible to healthy individuals in daily life. Everyone should be able to customise their health and wellness in accordance with their own genetic predisposition thanks to such personalised healthcare.